RAID-6 is probably killing you under heavy multi-file load. This is the case for both hardware and software raids.

XRootd/XCache can work with a set of independent disks and this scales much better, see page 12 of this:
https://indico.cern.ch/event/727208/contributions/3444604/attachments/1859894/3056280/XCache-FeaturesEtc-Lyon-2019.pdf
and of course the Holy docs:
http://xrootd.org/doc/dev49/ofs_config.htm#_Toc522916548
http://xrootd.org/doc/dev49/pss_config.htm#_Toc525070687

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