@simonmichal Thanks for the response. I just gave it a try. Unfortunately, the xrootd in brew is built with -DENABLE_PYTHON=OFF, so this is not something the new PyPI version solves.

Furthermore, I'm unable to install xrootd 5.3.0 via pip. It reports missing dependencies - openssl development package. Note that openssl is installed via brew (including the headers). However, the following is part of what brew prints when installing openssl:

    [log in to unmask] is keg-only, which means it was not symlinked into /opt/homebrew,
    because macOS provides LibreSSL.
    If you need to have [log in to unmask] first in your PATH run:
    echo 'export PATH="[log in to unmask]:$PATH"' >> ~/.zshrc
    For compilers to find [log in to unmask] you may need to set:
    export LDFLAGS="[log in to unmask]"
    export CPPFLAGS="[log in to unmask]"

Maybe the makefiles would need to be updated for use on M1 Macs?

In any case, I was able to compile with Python bindings from source and it works without problems. The steps are somewhat convoluted, so I'll write them here for others looking for a solution.

Compiling XRootD with Python bindings on M1 Macs

Run cmake like this

cmake -DENABLE_PYTHON=TRUE -DCMAKE_INSTALL_PREFIX=/opt/xrootd -DOPENSSL_ROOT_DIR=/opt/homebrew/opt/openssl ..

Edit CMakeCache.txt and change the following variables to point to the brew Python, like so:

PYTHON_EXECUTABLE:FILEPATH=/opt/homebrew/bin/python3
PYTHON_INCLUDE_DIR:PATH=/opt/homebrew/Frameworks/Python.framework/Versions/3.9/include/python3.9
PYTHON_LIBRARY:FILEPATH=/opt/homebrew/Frameworks/Python.framework/Versions/3.9/lib/libpython3.9.dylib

Run make and sudo make install
Add export PYTHONPATH=/opt/xrootd/lib/python3.9/site-packages:$PYTHONPATH to .zshrc/.bashrc/...
Confirm that it is working by running python3 -c "import pyxrootd"

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