So, for the record (as a lot was settled in private communication) a short summary with context, problem and workable solution for us (ALICE) is the following:

Context: one can have a system install xrootd python bindings (beside the --user installed one). the ALICE building framework, builds and install all it's software (including all python infrastructure) into it's own locations.
Problem: the running of installation command for python bindings (https://github.com/xrootd/xrootd/blob/v5.4.2/bindings/python/CMakeLists.txt#L93) was throwing the error:

Installing collected packages: xrootd
  Attempting uninstall: xrootd
    Found existing installation: xrootd 5.4.1
ERROR: Cannot uninstall 'xrootd'. It is a distutils installed project and thus we cannot accurately determine which files belong to it which would lead to only a partial uninstall.

this 5.4.1 being the system level installed package.

the solution was to modify https://github.com/xrootd/xrootd/blob/v5.4.2/bindings/python/CMakeLists.txt#L95
and add --ignore-installed (the simplest reason being that the name of argument seemed to imply what i wanted for the install to do)

moreover, maybe part of the context, i should mention that on clusters, or any multi-user machines, that xrootd might be needed system-level and this should not hinder the ALICE users to build the ALICE software;
moreover, while technically maybe possible, it's not in current mainstream/upstream usage the use of python venv (so, if i do so, i'm on my own, maybe i could manage, but here were are talking about ALL ALICE users that build the software); more so, implementation of pipx should be done by building framework developers, but among the current things, the priority for such a thing is really low..

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